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These future directions and ongoing developments are expected to accelerate the translation of AC from bench to bedside, ultimately expanding its therapeutic utility across diverse disease contexts

BioMed Pharmacother (2019) 110:3128

4.2 Potential targets and drugs for HDT in MTB with diabetes mellitus T2DM mice exhibit increased body weight, blood glucose levels, glucose tolerance, insulin resistance, and increased susceptibility to MTB infection

Heart A decrease in cardiac NAD + levels is causally linked to metabolic abnormalities and mitochondrial dysfunction, which contribute to the pathologies of heart failure [148,149,150]