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Moreover, the key oncogenic signaling pathways in TC (such as PI3K-AKT, MAPK, Wnt/-catenin, and HIF-1) can indirectly affect the activity of DNMT and TET by regulating the levels of key metabolic intermediates (such as acetyl coenzyme A and -glutamine) [42]

Based on mostly cell culture-based studies and a few animal models, it is possible that complex and diverse molecular mechanisms are involved in the anticancer activity of CBD