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95% CI 1.161.89) ( Furthermore, many of the flavouring agents used to enhance the appeal of e-cigarettesoften unregulated by toxicological standardspose additional respiratory risks ( One of the most serious vaping-related lung conditions is EVALI (E-cigarette or Vaping Product Use-Associated Lung Injury), first identified in 2019 in the United States ( 3.2.2 Cardiovascular effects Emerging evidence indicates that e-cigarette use may have deleterious cardiovascular effects, particularly when exposure begins during adolescence