key role of serine in glutathione transferase functions Frontiers Frontiers | Glutathione S-Transferases: Role

This enzyme was produced by fermentation with various microorganisms, particularly fungi from the Aspergillus and Penicillium genera ( Penicillium roqueforti strain could produce both tannase and GA simultaneously ( Aspergillus awamori strain BTMFW032, under deep fermentation conditions, was able to simultaneously produce GA and tannase, resulting in a 15-fold increase in the yields of both tannase and GA ( Rhodotorula pilimanae A45.2 and Bacillus spheroides have also been noted for their abilities to co-produce GA and tannase, with the latter achieving high efficiency in converting tannic acid to GA (90.80% crystallization), making it the most potent bacterial tannase producer for GA synthesis (Kanpiengjai et al., 2020

Yamada T, Horimoto H, Kameyama T, Hayakawa S, Yamato H, Dazai M, Takada A, Kida H, Bott D, Zhou AC, et al

Normal supplement doses do not show negative interactions

However, the clinical use of direct TNF- inhibitors for MASH has not yet been approved