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And, upon persistent inflammation and increased ROS levels, as observed during several psychiatric episodes, tissue antioxidant defense mechanisms are saturated to the point they become ineffective (Anderson and Maes, 2014)

Lahiguera , Hyroov P, Figueras A, et al

These complex control mechanisms contributing to UA homoeostasis reflect its importance in the human body

Specifically, Clostridium scindens (now known as Lachnoclostridium scindens ) is a pivotal functional species that mediates the conversion of primary bile acids into secondary bile acids via 7-dehydroxylation, thereby maintaining intestinal homeostasis and barrier integrity 181