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reported an increase in the levels of dysfunctional mitochondria and mitochondrial membrane proteins, translocase of the outer mitochondrial membrane 20 (Tom20), translocase of the inner mitochondrial membrane 23 (Tim23), and porin in the ASD temporal cortex without a change in the transcription of genes, such as PARK2 , responsible for the activation of mitophagy

Preclinical validation of a potent -secretase modulator for Alzheimers disease prevention

The animals were assessed one week thereafter, on day 10 after ligation

Meanwhile, validation of these findings in vivo will be an essential next step towards translating our results into clinical applications