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In experimental models, diabetes reduces NGF expression in target tissues including skin and muscle, impairing retrograde transport to neuronal cell bodies and decreasing neuropeptides such as substance P and calcitonin gene-related peptide [146]

One major factor contributing to this variability is interindividual anatomical diversity, which shapes both the magnitude and spatial distribution of the electric field within cerebellar structures

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These amphiphilic peptide nanoparticles represent promising candidates for future systemic gene delivery applications