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Further exploration into this domain could illuminate new pathways for intervention and management of these prevalent and challenging liver diseases

Data availability Data are available upon request to the corresponding author

They observed that hepatic I/R injury was attributed to a significant upregulation of pro-inflammatory cytokines in the kidneys 21

TRPV4 promotes PKC-dependent RhoA activation, forming stress fibers and resulting in damage to organs, such as the intestines, lungs, and brain (Laragione et al., 2019)