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[DOI] [PubMed] [Google Scholar] 27.Liz-Marzn LM, Mater

Bos PH, et al

Rather than simply co-administering two separate peptides, the team designed tirzepatide on the native GIP(1-42) backbone, then introduced specific amino acid substitutions at key positions to confer GLP-1 receptor cross-reactivity [6]