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Description

Osna NA, Rasineni K, Ganesan M, Donohue TM Jr, Kharbanda KK

Particularly at sites of inflammation, neutrophils have been reported to survive for up to 7 days due to the inhibition of cell apoptosis, an effect triggered by various inflammatory stimuli such as cytokines, pathogen-associated and damage-associated molecular pattern molecules (PAMPs and DAMPs) or environmental factors [45,46,47,48]

Passive release is the late stage of apoptosis, and the permeability of cell membrane increases, which leads to the passive release of HMGB1 to the extracellular space (105)