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For instance, a study on hepatocellular carcinoma demonstrated that an 8-oxoG modification at the third position of miR-122 promotes tumorigenesis, whereas further oxidation of the second nucleotide to yield 2,3o8G-miR-122 transforms it into a tumor-suppressive miRNA

Cell movement is guided by the rigidity of the substrate

Current literature predominantly elucidates linker chemistries, cytotoxic payloads, and pharmacokinetics tailored to tumor biology (Long et al., 2025)