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It exists as an active dimer 45 and targets phosphorylation of downstream targets such as CHK2, H2AX and p53 44,47,48,49

Certain groups at risk of deficiencies should use supplements: All pregnant and breastfeeding women should take vitamin D supplements Women trying to conceive and women in the first 12 weeks of their pregnancy are recommended to take folic acid supplements, which reduce their child's risk of neural tube defects such as spina bifida People aged 65 and over should take vitamin D supplements People with darker skin and people who are not exposed to much sun should take vitamin D supplements All children aged six months to five years should be given a supplement containing vitamins A, C and D Your doctor may also recommend supplements if you need them for a medical condition If you fall outside these groups and buy vitamin pills then the chances are that you will be spending your money on surplus amounts of vitamins you have already gained through your diet Lisa Rogers, from the World Health Organization, thinks that people are being overzealous in their ingestion of extra vitamins

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1169 / 2011, Anhang II