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Targeting VEGF-independent cords A number of different mechanisms, including the upregulation of other angiogenic pathways such as the Notch pathway, have been described to play a role in the development of tumor vessels that are insensitive to anti-VEGF therapy [4, 14, 15, 34]

Whereas several prospective studies provided evidence that elevated blood homocysteine concentration is a major independent causative risk factor for atherothrombotic disease (Arnesen et al, 1995

The practical limitation is that not all research facilities have access to minus eighty freezers, and the energy costs of maintaining such equipment can be substantial

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