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Furthermore, the Guest and Prentoe designs included the hydrophobic regions at the C-termini of E1 (residues 326352) and E2 (699717), which might explain why these constructs mostly produce as higher molecular weight aggregates (~700 kDa) 37

Drug Design, Development and Therapy 9:2485-2499

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Since its identification in the 1990s by the research group of Sikiric et al., it has become one of the most extensively studied peptides in tissue repair research, with published data spanning tendon healing, angiogenesis, nitric oxide regulation, and gastrointestinal cytoprotection