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While the beneficial effects of low IGF-1 action on aging seems well supported by data in model systems 6,7 and unique human populations 13,16 , a broader examination of the literature suggests that a more nuanced, complex, and controversial relationship exists between IGF-1, aging, and disease, which is indicative of the pleiotropic actions attributed to IGF-1 in cells and tissues 12,19

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The potential of hydrogen sulfide (H 2 S) donors, purinergic receptor blockers, and STING pathway inhibitors in reducing neuroinflammation and promoting neuronal recovery should be explored

10.1016/j.envres.2021.111531 34 WangY.FangZ.ZhaiQ.CuiS.ZhaoJ.ZhangH.et al