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Michael Bloomberg, a fierce detractor of e-cigarettes, warns without any clinical evidence that adolescent vapers risk IQ losses of up to 15 points for the rest of [their] life. The CDC states that nicotine can harm brain development, which continues until about age 25. Prominent anti-smoking organizations and the surgeon general also forecast bad outcomes

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inhibiting the synthesis of mucus, the substance that helps protect the intestinal tract from inflammation and infections changing mucus composition causing an imbalance in the gut bacterial community between beneficial and harmful strains increasing cell death in the tissue lining the intestine increasing inflammation Smoking and liver disease The development of liver cancer may accelerate in people with chronic hepatitis infections