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To a stirred solution of 3-(3-(difluoromethoxy)phenyl)-4,4-difluoro-1-(tetrahydro-2H-pyran-4-yl)-4,5,6,7-tetrahydro-TH-indazole-6-carboxylic acid (55.6 mg, 0.13 mmol) in DMF (0.6 mL) was added DIPEA (0.11 mL, 0.65 mmol), HATU (59.2 mg, 0.16 mmol), and 3-amino-3-methyltetrahydrothiophene 1,1-dioxide (23.2 mg, 0.16 mmol)

5 Discussion Normal microbiome and the human body to live in harmony, through the microbiome of digestion, decomposition, promote the absorption of the role of the host better, the host can also provide a good environment for its habitat