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STEP Trials and Formal Obesity Indication The STEP trials played a crucial role in gathering evidence to establish semaglutides formal indication for weight management in adults with obesity or overweight, ultimately leading to its approval in the US, Europe, UK, and Canada

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Given that the majority of mitochondria are localized within axons and are essential for axonal transport and energy homeostasis, mitochondrial impairment is likely to contribute to axonal degeneration and the development of neuropathic pain [64, 65]

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