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In the absence of phosphorylation during the early G1 phase, pRb engages with E2F transcription factors and suppresses the transcription of the E2F-regulated genes

J Immunol 170:43624372 Ganor Y, Teichberg VI, Levite M (2007) TCR activation eliminates glutamate receptor GluR3 from the cell surface of normal human T cells, via an autocrine/paracrine granzyme B-mediated proteolytic cleavage

We suggest that, with encouraging evidence of therapeutic effects and increasing insights into the mechanisms of action, randomized controlled trials should be conducted to elucidate a foundation for the clinical use of the KD

It dampens inflammatory cytokine signaling