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Funding This research was supported by the National Natural Science Foundation of China (30900163), Key Research Projects of Higher Education Institutions in Henan Province (24A210011), and College Students Innovative Entrepreneurial Training Plan Program (2023CX162)

The remaining 2 studies had an unclear overall risk of bias

For instance, increasing plasma glycine through injections may transiently augment inhibitory neurotransmission (potentially producing a mild sedative or muscle-relaxant effect) and support anabolic processes such as collagen deposition or antioxidant synthesis

Oral supplements need consistent, long-term use with questionable cost-effectiveness given the temporary results