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*Correspondence: Chen Chen, [email protected] Guo, [email protected] These authors have contributed equally to this work This article was submitted to Molecular Signalling and Pathways, a section of the journal Frontiers in Molecular Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Potency and PK anchors: Lau 2015 (cAMP EC50 6.2 pmol/L), Boianelli 2024 (free fraction 0.36%), FDA 2021 (weight-change EC50 54.6 nmol/L)

We confirm BMI eligibility and review contraindications before proceeding