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Description

Topical BCl-2 inhibitor (ABT-737) attenuates skin photoaging in mice

Peripheral studies report reduced AQP4 and tyrosine hydroxylase (TH) mRNA levels, alongside elevated proline-rich basic protein (PBP), pointing to systemic dysregulation of astrocytic functions, including water transport and neurotransmitter metabolism (Thamizh Thenral and Vanisree, 2012)