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4.2 Combined strategies of immune, antivascular, and radiotherapy based on metabolic pathways Metabolic remodeling, vascular normalization, and T-cell infiltration can form a synergistic cascade: inhibiting HIFVEGF signaling and dysregulated lipid metabolism may reduce myeloid-mediated immunosuppression, improve perfusion and oxygenation, and enhance CD8+ T-cell effector function, thereby providing a metabolic rationale for synergy between TKIs/VEGF inhibitors and ICIs