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IFN can form an important anti-ferroptosis system with SLC3A2 ( 6.5 Ferroptosis and cuproptosis Cuproptosis is defined as the aggregation of proteins, proteotoxic stress, and eventual cell death triggered by copper binding to the lipolytic enzymes of the tricarboxylic acid (TCA) cycle

Studies have shown that those with hypothyroidism have an altered composition of gut bacteria with reduced populations of the beneficial short-chain fatty acid (SCFA)-producing bacteria, and higher levels of inflammation-driving lipopolysaccharides (LPS)-producing bacteria

This lack of clarity not only hinders regulatory approval but also slows down clinical acceptance, underscoring the need for standardized assessment parameters

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