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Li, X., Wu, T

Up-regulating SreBP-1 expression raises the activities of fatty acid synthase and acetyl coenzyme A carboxylase, which stimulates the production of fatty acids and cholesterol and causes abnormal lipid buildup in renal tubular cells[41]

Specifically, animal studies show MPs can disrupt the -diversity of gut microbiota and decrease the Firmicutes-to-Bacteroidetes (F/B) ratio, resulting in an increased relative abundance of pathogenic bacteria in ICR mice (Wang et al., 2002), which are critical factors in the pathogenesis of neurodegenerative diseases

Moreover, they documented reduced hippocampal plasticity genesalongside a change in the rodents behavior (Venkidesh et al., 2023)