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In the phase 3 REDEFINE 1 trial, the combination of cagrilintide and semaglutide yielded a mean 20% reduction in body weight over 68 weeks in adults with overweight or obesity, significantly outperforming placebo and either agent alone

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Signs your dose needs adjustment Increase dose consideration: Minimal response after 3-4 weeks at current dose, stable weight and measurements despite consistent protocol adherence, absence of any subjective improvements in energy or fasted tolerance