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Thus, the longer survival of patients with higher IGF-1 levels could be related to direct biological actions of IGF-1, to an overactivation of a protective GH-IGF-1 pathway or to altered IGF-1 levels in patients with a favorable metabolic status

: "Overexpression of glutathione peroxidase 1 predicts poor prognosis in oral squamous cell carcinoma." in: Journal of cancer research and clinical oncology , Vol