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Folate plays a role in transferring one-carbon units to various intermediates in DNA synthesis and methylation reactions, including the conversion of homocysteine to methionine ( Literature indicates that nearly one-third of psychiatric and psychogeriatric hospital admissions exhibit low red cell folate levels or decreased serum folate levels, even in the absence of anemia or macrocytosis (65)

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Hepcidin, the master regulator of iron egress, may further refine risk stratification, as low hepcidin levels have been associated with a higher incidence of HF and mortality, potentially reflecting a state of functional iron deficiency [227, 387]