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Regulated exocytosis of GABA-containing synaptic-like microvesicles in pancreatic beta-cells

Notably, these alterations were not based on suppressed glycolysis, as BHB + T cells retained their glycolytic capacity (Fig EV1B and C)

10.26355/eurrev_202012_24046 Eur Rev Med Pharmacol Sci

In vivo experiments confirmed that the MPO/HOCl signaling pathway was significantly activated in the plasma and neurons of SOD1 G93A transgenic mice, which upregulated Caspase-3 expression, downregulated GPX4 and NQO1 expression, significantly elevated plasma MDA levels, promoted neuronal apoptosis, ferroptosis, and lipid peroxidation, and reduced motor performance in mice (Peng et al., 2022)