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This is a concern that applies to all significant weight loss interventions, not just tirzepatide, but it becomes more relevant as the magnitude of weight loss increases

J Cell Biol 161:281294 Hendus-Altenburger R, Fernandes CB, Bugge K, Kunze MBA, Boomsma W, Kragelund BB (2019) Random coil chemical shifts for serine, threonine and tyrosine phosphorylation over a broad pH range