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2.6 Histology and immunohistochemistry of PDX models For histopathological analysis, 5 m sections of formalin fixed paraffin embedded (FFPE) tumor samples were deparaffinized in ROTICLEAR (Carl Roth GmbH, Karlsruhe, Germany) and rehydrated using ethanol and distilled water

Therefore, we administered the ferroptosis inducers RSL-3 and DHA, both targeting the GPX4 protein, which uses GSH as a reducing agent to catalyze the reduction of lipid peroxides into the corresponding alcohols (Fig