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[124] We sought input on the following questions: What non-claims-based indicators could be used to improve payment accuracy and reduce health disparities, and how can CMS ensure that they are collected uniformly and documented consistently without unduly increasing administrative burden

For example, in colorectal cancer, p53 non-transcriptionally inhibits dipeptidyl peptidase 4 activity to prevent Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-mediated lipid peroxidation and erastin-induced ferroptosis, whereas TP53 deficiency enhances this process [46,47]

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