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With the development of time and technology, immunotherapeutic approaches for various leukemias have shown great promise, such as CD33 or CLL-1-specific chimeric antigen receptor (CAR)-T cell therapy[2, 3] and immune checkpoint inhibitor therapies such as TIM3, CD47, and anti-CD70 [4,5,6]

Moreover, providing recombinant STAT3-activated cytokines that directly target hepatocytes, specifically IL-11 and IL-22, may be another novel pro-regenerative therapeutic option for patients with difficult-to-treat APAP-induced ALF [218]

Laser resurfacing : Fractional laser treatments can tighten skin, improve pigmentation, and stimulate collagen remodeling

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