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Its levels within a cell must be tightly regulated, as deficiencies can lead to apoptosis and a surplus can lead to toxic build-up of reactive oxygen species produced via the Fenton reaction (Thomas et al

The second group was also cultured in normoxia, and NEM was used to clean up the biological thiols

This adhesion enables fibroblasts to spread and exert mechanical forces on the surrounding ECM, maintaining a "youthful" phenotype characterized by the preservation of ECM composition and structural organization