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In the co-culture system of VECs and VSMCs under high glucose and high phosphorus microenvironment, VECs secrete a large amount of lactate, which directly leads to the transformation of VSMC osteogenesis

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Furthermore, several preclinical studies have shown that metformin in combination with PD-1 inhibitors inhibits the growth of cancer cells in mouse models of different tumor types and leads to a significant increase in the number of tumor-infiltrating CD8 + T cells [397, 398]

doi:10.1007/s10741-020-09977-1