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Second, PCT guidance does not mean a standard approach, as studies applied different PCT protocols: 16 out of 26 included studies used PCT protocol to stop ABs, 3 used PCT protocol to start ABs, while 7 used PCT guidance for both starting and stopping AB therapy

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Individuals are also informed that treatment success is considered a 50% improvement in pain severity and frequency

The biologically active forms of selenium include total selenium concent, specific chemical species (such as SeMet, SeCys, selenocysteine (SeCys2), Se-methylselenocysteine (SeMeSeCys), selenate, and selenite), as well as functional selenoproteins like glutathione peroxidase 3 (GPX3) and SELENOP glutathione peroxidase (GPx) enzymatic activity 4,6