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reviewed by Anjum et al., The causal relationships of Pro accumulation and significance of GSH metabolism with enhanced tolerance to single stress factor (either metal or salinity) have been reported extensively in separate studies using natural variants, mutants or transgenic plants (Matysik et al., Nevertheless, owing to the facts that: (a) deficiency of S and N has become extensive in agricultural soils on the globe (reviewed by Anjum et al., Conflict of interest statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest