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In the thalamus, however, PDH activity was affected twice as much as TKT activity ( In cases of severe thiamine deficiency, however, a broad enzymatic deficiency encompassing all three mitochondrial TPP-dependent enzymes would be expected to result in symptoms similar to those of the genetic disorder dihydrolipoamide dehydrogenase (DLDD) deficiency (OMIM 246900)

Before we learn about the differences between bacteriostatic vs sterile water, let us first go through each of them one by one