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The National Institutes of Health estimates that as many as 90 percent of alcoholics also smoke cigarettes, and even those without an alcohol dependency are known to light up only when they drink. Although this link between drinking and smoking has been widely acknowledged, scientists are not completely sure of what entices drinkers to light up in the first place

Since protease release is mediated by immune cell activation and may lag behind nicotine T max , peak protease levels do not necessarily coincide temporally with peak nicotine levels 66