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Some of the apparently contradictory findings outlined below may be partially explained by differences in the models of CS-extract generation (filtered or unfiltered CS, extraction in physiologic media, buffered media or organic extracts, solubilization of smoke material captured on a filter, acute or prolonged exposure, etc.) and in vivo CS exposure (nose cone exposure, whole-body exposure, and challenge of animals by intra-tracheal CS-extracts)

Compared to Europe, U.S

Nat Rev mol Cell Biol

Its what makes cigarettes addictive, but it isnt the main reason smoking causes serious health harm, most of that comes from burning tobacco and breathing in the smoke