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322,323 In two ACG position papers (2018 and 2021) on the management of IBS, loperamide is not recommended as a first-line therapy due to the limited trials and small number of patients included, as well as its inability to improve global IBS symptoms

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ClinicalTrialsRegister.eu [online], (2014)

Synthesis of Results The primary meta-analysis pooled all RCTs across depression rating scales using standardized mean difference (SMD) random effects (REML)