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Recent research has unveiled new microglia-lymphocyte interactions in ischemic stroke, particularly the Spp1-Ptger4 pathway involved with macrophage-exhausted CD8 + T cells (Zheng et al., 2022)

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Understanding the warburg effect: the metabolic requirements of cell proliferation

Therefore, recovery from stroke likely requires re-mapping lost function onto surviving neural circuitry through structural and functional plasticity [82, 83]