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While the 2009 Family Smoking Prevention and Tobacco Control Act requires pictorial warnings on cigarette packaging, implementation was stalled by a 2012 lawsuit filed by the tobacco industry

Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2012 [accessed 2016 Apr 14]

Toward a comparative overview of dependence potential and acute toxicity of psychoactive substances used nonmedically

For more advanced or persistent cases, especially when prior treatments like chemoradiation fail, a more extensive surgical option known as abdominoperineal resection (APR) may be necessary