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JAMA 307 , 491 (2012)

Sodium-glucose cotransporter 2 inhibition suppresses HIF-1-mediated metabolic switch from lipid oxidation to glycolysis in kidney tubule cells of diabetic mice

However, co-expression of NcEgt1 and NcEgt2 led to a slightly decrease in EGT yield, which may be attributed to feedback inhibition caused by the accumulation of hercynine following Egt1 gene integration (Pluskal et al