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While these findings provide mechanistic plausibility for L-carnitine's effects on IR, most evidence derives from animal or cellular models, with limited human histological validation or pathway-intervention studies

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12-hour light/dark cycle) with ad libitum access to food and water, and were acclimatized for seven days prior to experimentation

This enhanced stability was attributed to the coordination of Zn with phenolic hydroxyl groups, which effectively prevented EGCG auto-oxidation and hydrolysis