Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-Exatecan Size:25mg Product Name Azide-Dap(m-PEG4)-Val-Cit-OH Synonyms CAS

Product Name Azide-Dap(m-PEG4)-Val-Cit-OH Synonyms CAS Number Related CAS Molecular Formula C24H44N8O10 Molecular Weight 604

Product Name [(4-bromophenyl)methyl]((methyl-d3))amine Synonyms [(4-bromophenyl)methyl]((²H3)methyl)amine CAS Number n/a Related CAS Molecular Formula C8H10BrN Molecular Weight 203

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Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma

Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-Exatecan Size:25mg Product Name Azide-Dap(m-PEG4)-Val-Cit-OH Synonyms CASSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG6 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I