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For instance, Fer-1, similar to other hydrophobic drug candidates, is unsuitable for clinical development because of its limited capacity to traverse the blood-brain barrier (BBB) and its poor water solubility [216]

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The counterfactual here matters for current patients: how many people today are depleted without knowing it because redox panels still aren't part of routine metabolic screening

The method comprises oral administration of a liposome suspension of reduced glutathione) where at least 30% of the reduced glutathione is entrapped in the aqueous spaces of the liposomes and therefore protected from degradation in the GI tract