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Glycemic biomarker assessment to confirm diabetic status in the DFU model before QCN-HS treatment As shown in Table 4, the DFU-GP group exhibited significantly higher fasting glucose and HbA1c levels, along with lower fasting insulin and increased HOMA-IR compared with non-diabetic controls, confirming a state of hyperglycemia and insulin resistance

44 The principles of the Redox Code were raised in 2015, 45 including the regulation of NADH and NADPH systems in metabolism, dynamic control of thiol switches in the redox proteome, activation and deactivation cycles of H 2 O 2 production, and the response of redox signaling to environmental changes at various cellular levels, paved the way for new insights into disease-specific therapeutic targets through advanced biotechnological exploration of redox proteomics

Grozio, A