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Hereditary cancer syndromes like BRCA1/2 mutations, Lynch syndrome, and Li-Fraumeni syndrome create elevated lifetime cancer risk that persists regardless of current cancer status

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Vaccine efficacy studies determine how protective vaccine regimens are in a given cohort using defined end points , e.g., efficacy against symptomatic infection or against admission to intensive care

However, accumulating ChIP-seq data indicates that NRF2 predominantly binds intronic or distal intergenic regions (Malhotra et al, 2010