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The role of reactive oxygen species in acute myeloid leukaemia

10.1155/2018/2780272 J

The moderate form can cause a build up of acid in the body (metabolic acidosis), which can lead to nausea, fatigue, and vomiting

2.3.3 Aryl hydrocarbon receptor and abnormal expression of hepatocyte metabolic enzymes The AhR, functioning as a xenobiotic sensor, is most classically known as the primary transcriptional regulator of the cytochrome P450 (CYP) enzyme system, particularly the CYP1 family, thereby dominating Phase I metabolism of numerous foreign compounds in the liver